"CAPN3" Related Products

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Recombinant Human CAPN3, His-tagged

Cat.No.: CAPN3-26374TH
Product Overview: Recombinant fragment, corresponding to amino acids 500-734 of Human FAM111B, fused to His tag, 35kDa.
Description: Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed.
Conjugation: HIS
Source: E. coli
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 1X PBS
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Gene Name: CAPN3 calpain 3, (p94) [ Homo sapiens ]
Official Symbol: CAPN3
Synonyms: CAPN3; calpain 3, (p94); LGMD2, LGMD2A; calpain-3; CANP3; nCL 1; p94;
Gene ID: 825
mRNA Refseq: NM_000070
Protein Refseq: NP_000061
MIM: 114240
Uniprot ID: P20807
Chromosome Location: 15q15.1
Pathway: Integrin-mediated cell adhesion, organism-specific biosystem; TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem;
Function: calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cysteine-type peptidase activity; peptidase activity; signal transducer activity;

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