Recombinant Human HIV-1 Tat Interactive Protein 2, 30kDa, His-tagged

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Recombinant Human HIV-1 Tat Interactive Protein 2, 30kDa, His-tagged

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Cat. No. : HTATIP2-2723H
Product Overview : Recombinant humanHTATIP2 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 29.3 kDa (262aa),confirmed by MALDI-TOF.
Description : HTATIP2, also known as TIP30, is a member of the short-chain dehydrogenases/reductases (SDR) family. It acts as a tumor suppressor participating in metabolic suppression, inhibition of angiogenesis and induces the expression of apoptosis related genes Bad and Siva. HTATIP2 interacts with the activation domain of HIV-1 TAT and enhances its transcription by phosphorylating RNA polymerase II (Pol II). Defects in This protein are associated with hepatocellular carcinomas and apoptotic resistant tumor cells, suggesting a potential use for HTATIP2 in antitumor therapy.
Source : E.coli.
Sequences Of Amino Acids : MGSSHHHHHH SSGLVPRGSH MAETEALSKL REDFRMQNKS VFILGASGET GRVLLKEILE QGLFSKVTLI GRRKLTFDEE AYKNVNQEVV DFEKLDDYAS AFQGHDVGFC CLGTTRGKAG AEGFVRVDRD YVLKSAELAK AGGCKHFNLL SSKGADKSSN FLYLQVKGEV EAKVEELKFD RYSVFRPGVL LCDRQESRPG EWLVRKFFGS LPDSWARGHS VPVVTVVRAM LNNVVRPRDK QMELLENKAI HDLGKAHGSL KP
Form : Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 1mM DTT.
Purity : > 95% by SDS – PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
PDB rendering based on 2bka. :

Gene Name : HTATIP2 HIV-1 Tat interactive protein 2, 30kDa [ Homo sapiens ]
Synonyms : HTATIP2; HIV-1 Tat interactive protein 2, 30kDa; oxidoreductase HTATIP2; Tat-interacting protein (30kD); HIV-1 TAT-interactive protein 2; 30 kDa HIV-1 TAT-interacting protein; short chain dehydrogenase/reductase family 44U, member 1; EC 1.1.1.-; CC3; TIP30; SDR44U1; FLJ26963
Gene ID : 10553
mRNA Refseq : NM_001098520
Protein Refseq : NP_001091990
MIM : 605628
UniProt ID : Q9BUP3
Chromosome Location : 11p15.1
Function : NAD or NADH binding; RNA polymerase II transcription factor activity; oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; protein binding; transcription coactivator activity

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