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Recombinant Human CD163

Cat.No. : CD163-27220TH
Product Overview : Recombinant fragment of Human CD163 with a proprietary tag: predicted molecular weight 35.64 kDa.
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  • Gene Information
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Description : The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Protein length : 91 amino acids
Molecular Weight : 35.640kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed a
Biological activity : Useful for Antibody Production and Protein Array
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.79% Tris HCl, 0.31% GlutathioneNote: Glutathione is reduced
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : NGWSMEAVSVICNQLGCPTAIKAPG WANSSAGSGRIWMDHVSCRGNESAL WDCKHDGWGKHSNCTHQQDAGVTCS DGSNLEMRLTRGGNMC
Sequence Similarities : Contains 9 SRCR domains.
Gene Name : CD163 CD163 molecule [ Homo sapiens ]
Official Symbol : CD163
Synonyms : CD163; CD163 molecule; CD163 antigen; scavenger receptor cysteine-rich type 1 protein M130; M130; MM130;
Gene ID : 9332
mRNA Refseq : NM_004244
Protein Refseq : NP_004235
MIM : 605545
Uniprot ID : Q86VB7
Chromosome Location : 12p13
Function : protein binding; scavenger receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does CD163 contribute to the understanding of cardiovascular diseases? 03/17/2021

CD163 is implicated in the development and progression of cardiovascular diseases, serving as a marker for inflammation in atherosclerosis.

In what ways does CD163 contribute to the understanding of cancer progression? 07/30/2019

CD163 expression is studied in the context of cancer to evaluate its role in promoting or inhibiting tumor growth and metastasis.

How is CD163 involved in the pathogenesis of neurodegenerative diseases? 03/30/2017

CD163 is being investigated for its potential role in neurodegenerative diseases, where neuroinflammation is a key factor.

Are there diagnostic assays or imaging techniques that utilize CD163 as a molecular target? 11/10/2016

Some diagnostic assays and imaging techniques use CD163 as a molecular target to visualize and quantify inflammatory processes in vivo.

How is CD163 linked to autoimmune disorders such as lupus? 01/20/2016

CD163 expression is associated with the pathogenesis of autoimmune disorders, and its modulation is being explored for therapeutic purposes.

Customer Reviews (3)

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Reviews
01/25/2023

    The outstanding performance of CD163 protein in both ELISA and protein electron microscopy structure analysis positions it as a highly valuable asset in diverse research areas.

    09/09/2019

      Its ability to accurately detect proteins and visualize their structures offers a valuable toolkit for advancing scientific understanding and discoveries.

      01/13/2016

        Whether it is protein-protein interactions, enzymatic assays, or cellular studies, CD163 protein delivers consistent and accurate data, making it a valuable tool for researchers.

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