Recombinant Human CD247

• Cat.No.: CD247-27869TH
• Product Overview: Recombinant full length protein of Human CD3 zeta with proprietary tag; Predicted MWt 43.76 kDa inclusive of tag.

Specification

• Description: The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
• Protein length: 164 amino acids
• Molecular Weight: 43.760kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.31% Glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MKWKALFTAAILQAQLPITEAQSFG LLDPKLCYLLDGILFIYGVILTALF LRVKFSRSADAPAYQQGQNQLYNEL NLGRREEYDVLDKRRGRDPEMGGKP QRRKNPQEGLYNELQKDKMAEAYSE IGMKGERRRGKGHDGLYQGLSTATK DTYDALHMQALPPR
• Sequence Similarities: Belongs to the CD3Z/FCER1G family.Contains 3 ITAM domains.

Gene Information

• Gene Name: CD247 CD247 molecule [ Homo sapiens ]
• Official Symbol: CD247
• Synonyms: CD247; CD247 molecule; CD3Z, CD3z antigen, zeta polypeptide (TiT3 complex) , CD247 antigen; T-cell surface glycoprotein CD3 zeta chain; CD3H; CD3Q
• Gene ID: 919
• mRNA Refseq: NM_000734
• Protein Refseq: NP_000725
• MIM: 186780
• Uniprot ID: P20963
• Chromosome Location: 1q22-q25
• Pathway: Adaptive Immune System, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem
• Function: identical protein binding; protein binding; protein homodimerization activity; receptor activity; transmembrane signaling receptor activity