Recombinant Human CDC42BPA


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Recombinant Human CDC42BPA

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Cat.No. : CDC42BPA-26225TH
Product Overview : Recombinant fragment corresponding to N terminal amino acids 1-473 of human CDC42 binding protein kinase alpha , with an N-terminal tag, MW 73kDa. Expressed in baculovirus in sf9 insect cells.
Description : The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.
Tissue specificity : Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver.
Biological activity : Specific activity: 101nmol/min/mg.
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 CNH domain.Contains 1 CRIB domain.Contains 1 PH domain.Contains 1 phorbol-ester/DAG-type zinc finger.Contains 1
Gene Name : CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) [ Homo sapiens ]
Official Symbol : CDC42BPA
Synonyms : CDC42BPA; CDC42 binding protein kinase alpha (DMPK-like); CDC42 binding protein kinase alpha (DMPK like); serine/threonine-protein kinase MRCK alpha; FLJ23347; KIAA0451; MRCK; MRCKA; PK428;
Gene ID : 8476
mRNA Refseq : NM_003607
Protein Refseq : NP_003598
MIM : 603412
Uniprot ID : Q5VT25
Chromosome Location : 1q42.11
Pathway : CDC42 signaling events, organism-specific biosystem;
Function : ATP binding; identical protein binding; magnesium ion binding; nucleotide binding; protein binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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