Recombinant Human CDC42BPA

• Cat.No.: CDC42BPA-26225TH
• Product Overview: Recombinant fragment corresponding to N terminal amino acids 1-473 of human CDC42 binding protein kinase alpha , with an N-terminal tag, MW 73kDa. Expressed in baculovirus in sf9 insect cells.

Specification

• Description: The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.
• Tissue specificity: Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver.
• Biological activity: Specific activity: 101nmol/min/mg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 CNH domain.Contains 1 CRIB domain.Contains 1 PH domain.Contains 1 phorbol-ester/DAG-type zinc finger.Contains 1

Gene Information

• Gene Name: CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) [ Homo sapiens ]
• Official Symbol: CDC42BPA
• Synonyms: CDC42BPA; CDC42 binding protein kinase alpha (DMPK-like); CDC42 binding protein kinase alpha (DMPK like); serine/threonine-protein kinase MRCK alpha; FLJ23347; KIAA0451; MRCK; MRCKA; PK428
• Gene ID: 8476
• mRNA Refseq: NM_003607
• Protein Refseq: NP_003598
• MIM: 603412
• Uniprot ID: Q5VT25
• Chromosome Location: 1q42.11
• Pathway: CDC42 signaling events, organism-specific biosystem
• Function: ATP binding; identical protein binding; magnesium ion binding; nucleotide binding; protein binding