Recombinant Human CDH12 CDH12-26803TH

Recombinant Human CDH12

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Recombinant Human CDH12

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Cat.No. : CDH12-26803TH
Product Overview : Recombinant fragment of Human CDH12, amino acids 372-470 with a N terminal proprietary tag; Predicted MWt 36.52 kDa.
Description : This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.
Protein length : 99 amino acids
Molecular Weight : 36.520kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Brain.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : KISVLDVDEPPVFSK PLYTMEVYEDTPVGT IIGAVTAQDLDVGSS AVRYFIDWKSDGDSY FTIDGNEGTIATNEL LDRESTAQYNFSIIA SKVSNPLLT
Sequence Similarities : Contains 5 cadherin domains.
Gene Name : CDH12 cadherin 12, type 2 (N-cadherin 2) [ Homo sapiens ]
Official Symbol : CDH12
Synonyms : CDH12; cadherin 12, type 2 (N-cadherin 2); cadherin-12; Br cadherin; CDHB;
Gene ID : 1010
mRNA Refseq : NM_004061
Protein Refseq : NP_004052
MIM : 600562
Uniprot ID : P55289
Chromosome Location : 5p14.3
Pathway : Adherens junctions interactions, organism-specific biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem;
Function : calcium ion binding;

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