Recombinant Human CEBPA, His-tagged

• Cat.No.: CEBPA-27009TH
• Product Overview: Recombinant fragment, corresponding to amino acids 270/358 of Human CEBP Alpha bZip region, with His tag.

Specification

• Description: The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.
• Conjugation: HIS
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 5mM Beta mercaptoethanol, 20mM Tris HCl, 100mM Sodium chloride, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMGAGKAKKSVDKNS NEYRVRRERN NIAVRKSRDK AKQRNVETQQKVLELTSDND RLRKRVEQLS RELDTLRGIF RQLPESSLVKAMGNCA
• Sequence Similarities: Belongs to the bZIP family. C/EBP subfamily.Contains 1 bZIP domain.

Gene Information

• Gene Name: CEBPA CCAAT/enhancer binding protein (C/EBP), alpha [ Homo sapiens ]
• Official Symbol: CEBPA
• Synonyms: CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha; CEBP; CCAAT/enhancer-binding protein alpha; C/EBP alpha
• Gene ID: 1050
• mRNA Refseq: NM_004364
• Protein Refseq: NP_004355
• MIM: 116897
• Uniprot ID: P49715
• Chromosome Location: 19q13.1
• Pathway: Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adipogenesis, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; Developmental Biology, organism-specific biosystem
• Function: DNA binding; protein binding; protein complex binding; protein domain specific binding; protein heterodimerization activity