Recombinant Human CFLAR CFLAR-28415TH

Recombinant Human CFLAR

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Recombinant Human CFLAR

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Cat.No. : CFLAR-28415TH
Product Overview : Recombinant full length Human FLIP ; 480aa, 55.3kDa.
Description : The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists.
Protein length : 480 amino acids
Molecular Weight : 55.300kDa
Source : E. coli
Tissue specificity : Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
Form : Liquid
Purity : by SDS-PAGE
Storage buffer : pH: 8.00Constituents:0.32% Tris HCl, 10% Glycerol
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MSAEVIHQVEEALDT DEKEMLLFLCRDVAI DVVPPNVRDLLDILR ERGKLSVGDLAELLY RVRRFDLLKRILKMD RKAVETHLLRNPHLV SDYRVLMAEIGEDLD KSDVSSLIFLMKDYM GRGKISKEKSFLDLV VELEKLNLVAPDQLD LLEKCLKNIHRIDLK TKIQKYKQSVQGAGT SYRNVLQAAIQKSLK DPSNNFRLHNGRSKE QRLKEQLGAQQEPVK KSIQESEAFLPQSIP EERYKMKSKPLGICL IIDCIGNETELLRDT FTSLGYEVQKFLHLS MHGISQILGQFACMP EHRDYDSFVCVLVSR GGSQSVYGVDQTHSG LPLHHIRRMFMGDSC PYLAGKPKMFFIQNY VVSEGQLENSSLLEV DGPAMKNVEFKAQKR GLCTVHREADFFWSL CTADMSLLEQSHSSP SLYLQCLSQKLRQER KRPLLDLHIELNGYM YDWNSRVSAKEKYYV WLQHTLRKKLILSYT
Sequence Similarities : Belongs to the peptidase C14A family.Contains 2 DED (death effector) domains.
Gene Name : CFLAR CASP8 and FADD-like apoptosis regulator [ Homo sapiens ]
Official Symbol : CFLAR
Synonyms : CFLAR; CASP8 and FADD-like apoptosis regulator; CASP8AP1; c FLIP; CASH; Casper; CLARP; FLAME; FLIP; I FLICE; MRIT;
Gene ID : 8837
mRNA Refseq : NM_001127183
Protein Refseq : NP_001120655
MIM : 603599
Uniprot ID : O15519
Chromosome Location : 2q33-q34
Pathway : Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem;
Function : cysteine-type endopeptidase activity; protein binding;

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