Recombinant Human CRADD, His-tagged

• Cat.No.: CRADD-28236TH
• Product Overview: Recombinant full length human RAIDD with His tag; 219 amino acids, 24.9kDa.

Specification

• Description: The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 20mM Tris, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MEARDKQVLR SLRLELGAEV LVEGLVLQYL YQEGILTENH IQEINAQTTG LRKTMLMLDI LPSRGPKAFD TFLDSLQEFP WVREKLKKAR EEAMTDLPAG DRLTGIPSHI LNSSPSDRQI NQLAQRLGPE WEPMVLSLGL SQTDIYRCKA NHPHNVQSQV VEAFIRWRQR FGKQATFQSL HNGLRAVEVD PSLLLHMLE
• Sequence Similarities: Contains 1 CARD domain.Contains 1 death domain.

Gene Information

• Gene Name: CRADD CASP2 and RIPK1 domain containing adaptor with death domain [ Homo sapiens ]
• Official Symbol: CRADD
• Synonyms: CRADD; CASP2 and RIPK1 domain containing adaptor with death domain; death domain-containing protein CRADD; RAIDD; RIP associated ICH1/CED3 homologous protein with death domain
• Gene ID: 8738
• mRNA Refseq: NM_003805
• Protein Refseq: NP_003796
• MIM: 603454
• Uniprot ID: P78560
• Chromosome Location: 12q21.33-q23.1
• Pathway: Apoptosis, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Ceramide signaling pathway, organism-specific biosystem; HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem; TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem
• Function: death domain binding; protease binding; protein binding; protein binding, bridging