"CRK" Related Products

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Recombinant Human CRK, His-tagged

Cat.No.: CRK-27823TH
Product Overview: Recombinant full length Human Crk p38 protein with an N terminal His-tag.
Description: This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Protein length: 224 amino acids
Conjugation: HIS
Molecular Weight: 25.000kDa
Source: E. coli
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, pH 8.0
Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGR
Sequence Similarities: Belongs to the CRK family.Contains 1 SH2 domain.Contains 2 SH3 domains.
Gene Name: CRK v-crk sarcoma virus CT10 oncogene homolog (avian) [ Homo sapiens ]
Official Symbol: CRK
Synonyms: CRK; v-crk sarcoma virus CT10 oncogene homolog (avian); v crk avian sarcoma virus CT10 oncogene homolog; adapter molecule crk;
Gene ID: 1398
mRNA Refseq: NM_005206
Protein Refseq: NP_005197
MIM: 164762
Uniprot ID: P46108
Chromosome Location: 17p13
Pathway: ARMS-mediated activation, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem;
Function: SH2 domain binding; SH3/SH2 adaptor activity; ephrin receptor binding; protein binding; protein phosphorylated amino acid binding;

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