Recombinant Human CSNK1E, His-tagged

• Cat.No.: CSNK1E-27871TH
• Product Overview: Recombinant fragment, corresponding to amino acids 168-416 of Human CK1 epsilon with N terminal His tag. MWt ~31 kDa

Specification

• Description: The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.
• Form: Lyophilised:Reconstitution with 115 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: (Amino acid sequence (Sequence determined by 5 Sequencing))RENKNLTGTARYASINTHLGIEQSRRDD LESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKM STPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLF RNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREH EREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVA STPASRIQPAGNTSPRAISRVDRERKVSMRLHRGAPANVS SSDLTGRQEVSRIPASQTSVPFDHLGK
• Sequence Similarities: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.Contains 1 protein kinase domain.

Gene Information

• Gene Name: CSNK1E casein kinase 1, epsilon [ Homo sapiens ]
• Official Symbol: CSNK1E
• Synonyms: CSNK1E; casein kinase 1, epsilon; casein kinase I isoform epsilon; HCKIE
• Gene ID: 1454
• mRNA Refseq: NM_001894
• Protein Refseq: NP_001885
• MIM: 600863
• Uniprot ID: P49674
• Chromosome Location: 22q13.1
• Pathway: Canonical Wnt signaling pathway, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Centrosome maturation, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Circadian rhythm - mammal, organism-specific biosystem
• Function: ATP binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity