Recombinant Human CUL1, His-tagged

• Cat.No.: CUL1-28050TH
• Product Overview: Recombinant fragment, corresponding to amino acids 525-776 of Human Cullin 1 with N terminal His tag; Predicted MWt 30 kDa.

Specification

• Description: Cullin1, also known CUL1, is a core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and tran
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Expressed in lung fibroblasts.
• Form: Lyophilised:Reconstitute with 83 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: LTNSEPLDLDFSIQVLSSGSWPFQQ SCTFALPSELERSYQ RFTAFYASRHSGRKLTWLYQLSKGE LVTNCFKNRYTLQ ASTFQMAILLQYNTEDAYTVQQLTD STQIKMDILAQVL QILLKSKLLVLEDENANVDEVELKP DTLIKLYLGYKNKKLRVNINVPMKT EQKQEQETTHKNIEEDRKLLIQAAI VRI MKMRKVLKHQQLLGEVLTQLSSRFK PRVPVIKKCIDIL IEKEYLERVDGEKDTYSYLA
• Sequence Similarities: Belongs to the cullin family.

Gene Information

• Gene Name: CUL1 cullin 1 [ Homo sapiens ]
• Official Symbol: CUL1
• Synonyms: CUL1; cullin 1; cullin-1
• Gene ID: 8454
• mRNA Refseq: NM_003592
• Protein Refseq: NP_003583
• MIM: 603134
• Uniprot ID: Q13616
• Chromosome Location: 7q36.1
• Pathway: APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Canonical Wnt signaling pathway, organism-specific biosystem
• Function: protein binding; ubiquitin protein ligase binding