Recombinant Human DAZL

• Cat.No.: DAZL-26122TH
• Product Overview: Recombinant full length Human DAZL with proprietary tag .

Specification

• Description: The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene.
• Protein length: 296 amino acids
• Molecular Weight: 58.190kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Testis specific.
• Biological activity: useful for Antibody Production and Protein Array
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.31% GlutathioneNote: Reduced glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the RRM DAZ family.Contains 1 DAZ-like domain.Contains 1 RRM (RNA recognition motif) domain.

Gene Information

• Gene Name: DAZL deleted in azoospermia-like [ Homo sapiens ]
• Official Symbol: DAZL
• Synonyms: DAZL; deleted in azoospermia-like; DAZLA; DAZH; DAZL1; MGC26406; SPGYLA
• Gene ID: 1618
• mRNA Refseq: NM_001190811
• Protein Refseq: NP_001177740
• MIM: 601486
• Uniprot ID: Q92904
• Chromosome Location: 3p24
• Pathway: Ovarian Infertility Genes, organism-specific biosystem
• Function: RNA binding; identical protein binding; mRNA 3-UTR binding; nucleic acid binding; nucleotide binding