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Recombinant Human DAZL

Cat.No.: DAZL-26122TH
Product Overview: Recombinant full length Human DAZL with proprietary tag .
Description: The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene.
Protein length: 296 amino acids
Molecular Weight: 58.190kDa inclusive of tags
Source: Wheat germ
Tissue specificity: Testis specific.
Biological activity: useful for Antibody Production and Protein Array
Form: Liquid
Purity: Proprietary Purification
Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.31% GlutathioneNote: Reduced glutathione
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the RRM DAZ family.Contains 1 DAZ-like domain.Contains 1 RRM (RNA recognition motif) domain.
Gene Name: DAZL deleted in azoospermia-like [ Homo sapiens ]
Official Symbol: DAZL
Synonyms: DAZL; deleted in azoospermia-like; DAZLA; DAZH; DAZL1; MGC26406; SPGYLA;
Gene ID: 1618
mRNA Refseq: NM_001190811
Protein Refseq: NP_001177740
MIM: 601486
Uniprot ID: Q92904
Chromosome Location: 3p24
Pathway: Ovarian Infertility Genes, organism-specific biosystem;
Function: RNA binding; identical protein binding; mRNA 3-UTR binding; nucleic acid binding; nucleotide binding;

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