"DCLK1" Related Products

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Recombinant Human DCLK1

Cat.No.: DCLK1-26808TH
Product Overview: Recombinant full length Human DCAMKL1 expressed in a Baculovirus infected Sf9 cell expression system with N-terminal proprietary tag, MWt 110kDa.
Description: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.
Protein length: 740 amino acids
Molecular Weight: 110.000kDa inclusive of tags
Source: Baculovirus
Tissue specificity: In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The ty
Biological activity: The Specific activity of DCLK1-26808TH was determined to be 3.4 nmol/min/mg.
Form: Liquid
Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Contains 2 doublecortin domains.Contains 1 protein kinase domain.
Gene Name: DCLK1 doublecortin-like kinase 1 [ Homo sapiens ]
Official Symbol: DCLK1
Synonyms: DCLK1; doublecortin-like kinase 1; DCAMKL1, doublecortin and CaM kinase like 1; serine/threonine-protein kinase DCLK1; DCDC3A; DCLK; KIAA0369;
Gene ID: 9201
mRNA Refseq: NM_001195415
Protein Refseq: NP_001182344
MIM: 604742
Uniprot ID: O15075
Chromosome Location: 13q13.3
Function: ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity;

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