||Recombinant fragment, corresponding to amino acids 85-258 of Human DIXDC1 with N terminal His tag; 174 amino acids, 20kDa.
||DIXDC1 belongs to the DIXDC1 family and contains 1 CH (calponin homology) domain and 1 DIX domain.The coiled coil domain mediates interaction with MAP3K4 and inhibition of AXIN1 mediated JNK activation through MAP3K4.The DIX domain mediates interaction with AXIN1 and inhibition of AXIN1 mediated JNK activation through MAP3K1. Probably also mediates interaction with DVL2.Functions as a positive effector of the Wnt signaling pathway. Regulates JNK activation by AXIN1 and DVL2.
||Lyophilised:Reconstitute with 141 μl aqua dest.
||Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
||Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
|Sequences of amino acids:
||VEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAA HFKPGSSRTVNQGRDSRAPLQSHRPHCATAVAQGAAAA LADVCHDMSRSGRDVFRYRQRNSSMDEEIENPYWSVRA LVQQYEGQQRSPSESSCSSLTSPSPIHSAKSESIITQSEE KADFVIIPAEGIENRTEG