Recombinant Human DOCK7, His-tagged DOCK7-28082TH

Recombinant Human DOCK7, His-tagged


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Recombinant Human DOCK7, His-tagged

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Cat.No. : DOCK7-28082TH
Product Overview : Recombinant fragment, corresponding to amino acids 1823-2109 of Human DOCK7 with a N terminal His tag; predicted MWt 35 kDa:
Description : DOCK7 functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. It does not have a GEF activity for CDC42. It is required for STMN1 Ser-15 phosphorylation during axon formation and consequently for neuronal polarization.
Conjugation : HIS
Source : E. coli
Form : Lyophilised:reconstitution with 69 μl aqua dest.
Storage buffer : Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Gene Name : DOCK7 dedicator of cytokinesis 7 [ Homo sapiens ]
Official Symbol : DOCK7
Synonyms : DOCK7; dedicator of cytokinesis 7; dedicator of cytokinesis protein 7; KIAA1771; ZIR2;
Gene ID : 85440
mRNA Refseq : NM_033407
Protein Refseq : NP_212132
Uniprot ID : Q96N67
Chromosome Location : 1p32.1
Pathway : ErbB2/ErbB3 signaling events, organism-specific biosystem; Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Hemostasis, organism-specific biosystem;
Function : GTP binding; GTPase binding; Rac GTPase binding; guanyl-nucleotide exchange factor activity;

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