||Recombinant fragment, corresponding to amino acids 1823-2109 of Human DOCK7 with a N terminal His tag; predicted MWt 35 kDa:
||DOCK7 functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. It does not have a GEF activity for CDC42. It is required for STMN1 Ser-15 phosphorylation during axon formation and consequently for neuronal polarization.
||Lyophilised:reconstitution with 69 μl aqua dest.
||Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
||Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
|Sequences of amino acids:
||DLDEQEFVYKEPAITKLAEISHRLEGFYGERFGEDVVEVI KDSNPVDKCKLDPNKAYIQITYVEPYFDTYEMKDRITY FDKNYNLRRFMYCTPFTLDGRAHGELHEQFKRKTILTT SHAFPYIKTRVNVTHKEEIILTPIEVAIEDMQKKTQELAF ATHQDPADPKMLQMVLQGSVGTTVNQGPLEVAQVFLSE IPSDPKLFRHHNKLRLCFKDFTKRCEDALRKNKSLIGP DQKEYQRELERNYHRLKEALQPLINRKIPQLYKAVLPV TCHRDSFSRMSLRKMDL