"DOT1L" Related Products


Recombinant Human DOT1L

Cat.No.: DOT1L-27742TH
Product Overview: Recombinant fragment, corresponding to amino acids 2-416 of Human KMT4 / Dot1L with N terminal proprietary tag, 73 kDa.
Description: The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes.
Source: E. coli
Form: Liquid
Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 7.5
Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Gene Name: DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) [ Homo sapiens ]
Official Symbol: DOT1L
Synonyms: DOT1L; DOT1-like, histone H3 methyltransferase (S. cerevisiae); histone-lysine N-methyltransferase, H3 lysine-79 specific; DOT1; histone methyltransferase DOT1L; KIAA1814; KMT4;
Gene ID: 84444
mRNA Refseq: NM_032482
Protein Refseq: NP_115871
MIM: 607375
Uniprot ID: Q8TEK3
Chromosome Location: 19p13.3
Pathway: Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem; Transcriptional misregulation in cancers, organism-specific biosystem; Transcriptional misregulation in cancers, conserved biosystem;
Function: DNA binding; histone-lysine N-methyltransferase activity; methyltransferase activity; protein binding; transferase activity;

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