||Recombinant fragment, corresponding to amino acids 167-452 of Human eIF2B3 with an N terminal His tag. Predicted MWt: 33 kDa;
||The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
||Lyophilised:Reconstitute with 66 μl aqua dest.
||Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
||Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
|Sequences of amino acids:
||LLFMANEADLDEELVIKGSILQKHPRIRFHTGLVDAHLYC LKKYIVDFLMENGSITSIRSELIPYLVRKQFSSASSQQ GQEEKEEDLKKKELKSLDIYSFIKEANTLNLAPYDACW NACRGDRWEDLSRSQVRCYVHIMKEGLCSRVSTLGLYMEA NRQVPKLLSALCPEEPPVHSSAQIVSKHLVGVDSLIGP ETQIGEKSSIKRSVIGSSCLIKDRVTITNCLLMNSVTV EEGSNIQGSVICNNAVIEKGADIKDCLIGSGQRIEAKAKRVNEVIVGNDQLMEI
||Belongs to the eIF-2B gamma/epsilon subunits family.