| Cat. No. : |
ANGPT4-1587H |
| Description : |
shares 45%, 47% and 54% aa sequence identity with human Ang-1, human Ang-2 and mouse Ang-3, respectively. Although the sequence homology is much higher between the human and mouse counterparts for Ang-1 (97%) and Ang-2 (85%), mouse Ang-3 is believed to be an ortholog of human Ang-4 based on chromosomal localization studies. Human Ang-4 is highly expressed in lung and in cultured human umbilical vein endothelial cells (HUVECs). In contrast, mouse Ang-3 is expressed multiple mouse tissues. Human Ang-4 is an agonist that can bind and activate Tie-2, a receptor tyrosine kinase with immunoglobulin and epidermal growth factor homology domains expressed primarily on endothelial cells and early hematopoietic cells. Mouse Ang-3 has been reported to be a Tie-2 antagonist. It is likely that mouse Ang-3, like Ang-2, may exert agonist or antagonist activities depending on the cell context. |
| Source : |
Mammalian cells |
| State Of Matter : |
Lyophilized. |
| Purity : |
>85% by SDS PAGE and analyzed by silver stain. |
| Endotoxin : |
<1.0 EU/µg as determined by the LAL method. |
| Molecular Weight : |
The predicted molecular weight of Recombinant Human Ang-4 is Mr 57 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 60-100 kDa. |
| Storage And Stability : |
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
