Recombinant Human ENSA protein, His-tagged
Cat.No. : | ENSA-28569TH |
Product Overview : | Recombinant Human ENSA (Ser2-Glu121) protein was fused to His-tag at N-terminus and expressed in E.coli. |
- Specification
- Gene Information
- Related Products
Description : | Alpha-endosulfine (ENSA),a member of the endosulfine family, is also known as ARPP-19e,which is widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas. ENSA is a protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, ENSA is able to specifically interact with PPP2R2D (PR55-delta) and inhibit its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). ENSA acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Ser2 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 14.2 kDa. The protein migrates as 18 kDa under reducing (R) condition (SDS-PAGE). |
Protein length : | Ser2-Glu121 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >90% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | ENSA |
Official Symbol : | ENSA |
Synonyms : | ENSA; endosulfine alpha; alpha-endosulfine; ARPP 19e; MGC4319; MGC8394; MGC78563; ARPP-19e |
Gene ID : | 2029 |
mRNA Refseq : | NM_004436 |
Protein Refseq : | NP_004427 |
MIM : | 603061 |
UniProt ID : | O43768 |
Products Types
◆ Recombinant Protein | ||
ENSA-1765R | Recombinant Rat ENSA Protein, His (Fc)-Avi-tagged | +Inquiry |
ENSA-2801M | Recombinant Mouse ENSA Protein, His (Fc)-Avi-tagged | +Inquiry |
Ensa-2834M | Recombinant Mouse Ensa Protein, Myc/DDK-tagged | +Inquiry |
ENSA-3328H | Recombinant Human ENSA Protein, GST-tagged | +Inquiry |
ENSA-5215M | Recombinant Mouse ENSA Protein | +Inquiry |
◆ Lysates | ||
ENSA-6593HCL | Recombinant Human ENSA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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