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Recombinant Human ENSA, His-tagged

Cat.No.: ENSA-28569TH
Product Overview: Recombinant full length Human ENSA fused to a His tag at the N terminus. Predicted mwt: 15.5 kDa;
Description: The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.
Conjugation: HIS
Source: E. coli
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MSQKQEEENP AEETGEEKQDTQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQKGQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTPQDLPQRKSSL VTSKLAGGQV E
Gene Name: ENSA endosulfine alpha [ Homo sapiens ]
Official Symbol: ENSA
Synonyms: ENSA; endosulfine alpha; alpha-endosulfine; ARPP 19e; MGC4319; MGC8394; MGC78563;
Gene ID: 2029
mRNA Refseq: NM_004436
Protein Refseq: NP_004427
MIM: 603061
Uniprot ID: O43768
Chromosome Location: 1q21.3
Function: ion channel inhibitor activity; phosphatase inhibitor activity; protein phosphatase 2A binding; protein phosphatase inhibitor activity; protein phosphatase type 2A regulator activity;

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