Recombinant Human ERCC8

• Cat.No.: ERCC8-26850TH
• Product Overview: Recombinant full length Human ERCC8 with N terminal proprietary tag, 69.56 kDa.

Specification

• Description: This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
• Protein length: 396 amino acids
• Molecular Weight: 69.560kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MLGFLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVER IHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQS YYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSF DKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVA VGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDY ILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENT LVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYT VYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILA WVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDEEG
• Sequence Similarities: Contains 5 WD repeats.

Gene Information

• Gene Name: ERCC8 excision repair cross-complementing rodent repair deficiency, complementation group 8 [ Homo sapiens ]
• Official Symbol: ERCC8
• Synonyms: ERCC8; excision repair cross-complementing rodent repair deficiency, complementation group 8; CKN1, Cockayne syndrome 1 (classical); DNA excision repair protein ERCC-8; CSA
• Gene ID: 1161
• mRNA Refseq: NM_000082
• Protein Refseq: NP_000073
• MIM: 609412
• Uniprot ID: Q13216
• Chromosome Location: 5q12.1
• Pathway: Cul4-DDB1-CSA complex, organism-specific biosystem; DNA Repair, organism-specific biosystem; Dual incision reaction in TC-NER, organism-specific biosystem; Formation of transcription-coupled NER (TC-NER) repair complex, organism-specific biosystem; Nucleotide Excision Repair, organism-specific biosystem
• Function: NOT DNA helicase activity; NOT DNA-dependent ATPase activity; protein binding; protein complex binding; contributes_to ubiquitin-protein ligase activity