Recombinant Human ETFB, His-tagged

• Cat.No.: ETFB-28404TH
• Product Overview: Recombinant full length Human ETFB with an N terminal His tag; 275 amino acids, predicted MWt 30kDa.

Specification

• Description: This gene encodes electron-transfer-flavoprotein, beta polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. The gene deficiencies have been implicated in type II glutaricaciduria. Alternatively spliced transcript variants have been found for this gene.
• Protein length: 255 amino acids
• Conjugation: HIS
• Molecular Weight: 30.000kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Abundant in liver, heart and skeletal muscle. A weak expression is seen in the brain, placenta, lung, kidney and pancreas.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 40% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, pH 8.0
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMAELR VLVAVKRVIDYAVKIRVKPDRTGVV TDGVKHSMNPFCEIAVEEAVRLKEK KLVKEVIAVSCGPAQCQETIRTALA MGADRGIHVEVPPAEAERLGPLQVA RVLAKLAEKEKVDLVLLGKQAIDDD CNQTGQMTAGFLDWPQGTFASQVTL EGDKLKVEREIDGGLETLRLKLPAV VTADLRLNEPRYATLPNIMKAKKKK IEVIKPGDLGVDLTSKLSVISVEDP PQRTAGVKVETTEDLVAKLKEIGRI
• Sequence Similarities: Belongs to the ETF beta-subunit/fixA family.

Gene Information

• Gene Name: ETFB electron-transfer-flavoprotein, beta polypeptide [ Homo sapiens ]
• Official Symbol: ETFB
• Synonyms: ETFB; electron-transfer-flavoprotein, beta polypeptide; electron transfer flavoprotein subunit beta
• Gene ID: 2109
• mRNA Refseq: NM_001014763
• Protein Refseq: NP_001014763
• MIM: 130410
• Uniprot ID: P38117
• Chromosome Location: 19q13.3-q13.4
• Pathway: Metabolism, organism-specific biosystem; Respiratory electron transport, organism-specific biosystem; Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., organism-specific biosystem; The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystem
• Function: electron carrier activity