Recombinant Human FBN1 FBN1-28892TH

Recombinant Human FBN1

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Recombinant Human FBN1

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Cat.No. : FBN1-28892TH
Product Overview : Recombinant fragment corresponding to amino acids 2772-2871 of Human Fibrillin 1 with an N terminal proprietary tag; Predicted MWt 36.63 kDa.
Description : This gene encodes a member of the fibrillin family. The encoded protein is a large, extracellular matrix glycoprotein that serve as a structural component of 10-12 nm calcium-binding microfibrils. These microfibrils provide force bearing structural support in elastic and nonelastic connective tissue throughout the body. Mutations in this gene are associated with Marfan syndrome, isolated ectopia lentis, autosomal dominant Weill-Marchesani syndrome, MASS syndrome, and Shprintzen-Goldberg craniosynostosis syndrome.
Protein length : 100 amino acids
Molecular Weight : 36.630kDa inclusive of tags
Source : Wheat germ
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : SNKVRILELLPALTT LTNHNRYLIESGNED GFFKINQKEGISYLH FTKKKPVAGTYSLQI SSTPLYKKKELNQLE DKYDKDYLSGELGDN LKMKIQVLLH
Sequence Similarities : Belongs to the fibrillin family.Contains 47 EGF-like domains.Contains 9 TB (TGF-beta binding) domains.
Gene Name : FBN1 fibrillin 1 [ Homo sapiens ]
Official Symbol : FBN1
Synonyms : FBN1; fibrillin 1; FBN, fibrillin 1 (Marfan syndrome) , MFS1, WMS; fibrillin-1; Marfan syndrome; MASS; OCTD; SGS;
Gene ID : 2200
mRNA Refseq : NM_000138
Protein Refseq : NP_000129
MIM : 134797
Uniprot ID : P35555
Chromosome Location : 15q21.1
Pathway : Integrin cell surface interactions, organism-specific biosystem; Signal Transduction, organism-specific biosystem;
Function : calcium ion binding; extracellular matrix structural constituent; protein binding;

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