Recombinant Human FGFR2
Cat.No. : | FGFR2-28889TH |
Product Overview : | Recombinant full length human FGFR2 Cytoplasmic domain with N-terminal proprietary tag expressed in a Baculovirus expression system, 74 kDa |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. |
Biological activity : | Specific Activity: 521.4 pmol/min/μg.Assay condition: The enzyme reaction was carried out for 1h at room temperature in a buffer containing 50 mM HEPES (pH7.5), 10 mM MgCl2, 1 mM EDTA, 0.01% BRIJ-35 and 200 μM of ATP. Substrate : 2 μM Tyr peptide 4. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 138mM Sodium chloride, pH 8.0 |
Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.Contains 3 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain. |
Gene Name : | FGFR2 fibroblast growth factor receptor 2 [ Homo sapiens ] |
Official Symbol : | FGFR2 |
Synonyms : | FGFR2; fibroblast growth factor receptor 2; bacteria expressed kinase , BEK, CFD1, craniofacial dysostosis 1 , Jackson Weiss syndrome , JWS, keratinocyte growth factor receptor , KGFR; CD332; CEK3; Crouzon syndrome; ECT1; K SAM; Pfeiffer syndrome; TK14 |
Gene ID : | 2263 |
mRNA Refseq : | NM_000141 |
Protein Refseq : | NP_000132 |
MIM : | 176943 |
Uniprot ID : | P21802 |
Chromosome Location : | 10q25.3-q26 |
Pathway : | Angiogenesis, organism-specific biosystem; Downstream signaling of activated FGFR, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; FGF signaling pathway, organism-specific biosystem; |
Function : | ATP binding; fibroblast growth factor binding; fibroblast growth factor binding; fibroblast growth factor-activated receptor activity; fibroblast growth factor-activated receptor activity; |
Products Types
◆ Recombinant Protein | ||
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◆ Lysates | ||
FGFR2-428HCL | Recombinant Human FGFR2 cell lysate | +Inquiry |
FGFR2-2578HCL | Recombinant Human FGFR2 cell lysate | +Inquiry |
FGFR2-001MCL | Recombinant Mouse FGFR2 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0341 | FGFR2 Kinase (Human) Assay/Inhibitor Screening Assay Kit | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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