Recombinant Human FHIT, His-tagged

• Cat.No.: FHIT-27014TH
• Product Overview: Recombinant full length Human FHIT with C terminal His tag; 155 amino acids with tag, MWt 17.9kDa.

Specification

• Description: This gene, a member of the histidine triad gene family, encodes a diadenosine 5,5-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene.
• Protein length: 147 amino acids
• Conjugation: HIS
• Molecular Weight: 17.900kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MSFRFGQHLI KPSVVFLKTE LSFALVNRKP VVPGHVLVCP LRPVERFHDL RPDEVADLFQ TTQRVGTVVE KHFHGTSLTF SMQDGPEAGQ TVKHVHVHVL PRKAGDFHRN DSIYEELQKH DKEDFPASWR SEEEMAAEAA ALRVYFQLEH HHHHH

Gene Information

• Gene Name: FHIT fragile histidine triad gene [ Homo sapiens ]
• Official Symbol: FHIT
• Synonyms: FHIT; fragile histidine triad gene; bis(5-adenosyl)-triphosphatase; AP3Aase; FRA3B
• Gene ID: 2272
• mRNA Refseq: NM_001166243
• Protein Refseq: NP_001159715
• MIM: 601153
• Uniprot ID: P49789
• Chromosome Location: 3p14.2
• Pathway: Non-small cell lung cancer, organism-specific biosystem; Non-small cell lung cancer, conserved biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem; Small cell lung cancer, organism-specific biosystem
• Function: bis(5-adenosyl)-triphosphatase activity; catalytic activity; hydrolase activity; nickel ion binding; protein binding