Native Human FN1


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Native Human FN1

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Cat.No. : FN1-28900TH
Product Overview : Full length Human Fibronectin , Heterodimer, 550kDa.
Description : This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined.
Tissue specificity : Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are f
Form : Lyophilised:Reconstitute with 1.0 milliliters of water to achieve 2.0 mg/mL.
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 20mM HEPES, 150mM Sodium chloride, pH 7.4
Storage : Store at 4°C. Upon reconstitution store at -80oC.
Sequence Similarities : Contains 12 fibronectin type-I domains.Contains 2 fibronectin type-II domains.Contains 16 fibronectin type-III domains.
Gene Name : FN1 fibronectin 1 [ Homo sapiens ]
Official Symbol : FN1
Synonyms : FN1; fibronectin 1; fibronectin; CIG; cold insoluble globulin; FINC; GFND2; LETS; migration stimulating factor; MSF;
Gene ID : 2335
mRNA Refseq : NM_002026
Protein Refseq : NP_002017
MIM : 135600
Uniprot ID : P02751
Chromosome Location : 2q34
Pathway : Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem;
Function : collagen binding; extracellular matrix structural constituent; heparin binding; protein binding;

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