Recombinant Human FOSB

• Cat.No.: FOSB-28107TH
• Product Overview: Recombinant fragment, corresponding to amino acids 113-151 of Human Fos B

Specification

• Description: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: SSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETLT
• Sequence Similarities: Belongs to the bZIP family. Fos subfamily.Contains 1 bZIP domain.

Gene Information

• Gene Name: FOSB FBJ murine osteosarcoma viral oncogene homolog B [ Homo sapiens ]
• Official Symbol: FOSB
• Synonyms: FOSB; FBJ murine osteosarcoma viral oncogene homolog B; protein fosB; activator protein 1; AP 1; DKFZp686C0818; GOS3; GOSB; G0S3; MGC42291; oncogene FOS B
• Gene ID: 2354
• mRNA Refseq: NM_001114171
• Protein Refseq: NP_001107643
• MIM: 164772
• Uniprot ID: P53539
• Chromosome Location: 19q13.3
• Pathway: Osteoclast differentiation, organism-specific biosystem; Osteoclast differentiation, conserved biosystem; TGF-beta Receptor Signaling Pathway, organism-specific biosystem
• Function: DNA binding; protein dimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor binding