Recombinant Human FSCN1, His-tagged

• Cat.No.: FSCN1-28387TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1-487 of Human Fascin with a N terminal His tag; Predicted MWt 54kDa:

Specification

• Description: This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkins lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Ubiquitous.
• Form: Lyophilised:reconstitution with 136 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MTANGTAEAVQIQFGLINCGNKYLT AEAFGFKVNASASSL KKKQIWTLEQPPDEAGSAAVCLRSH LGRYLAADKDGNV TCEREVPGPDCRFLIVAHDDGRWSL QSEAHRRYFGGTE DRLSCFAQTVSPAEKWSVHIAMHPQ VNIYSVTRKRYAHLS ARPADEIAVDRDVPWGVDSLITLAF QDQRYSVQTADHR FLRHDGRLVARPEPATGYTLEFRSG KVAFRDCEGRYLA PSGPSGTLKAGKATKVGKDELFALE QSCAQVVLQAANE RNVSTRQGMDLSANQDEETDQETFQ LEIDRDTKKCAFRTH TGKYWTLTATGGVQSTASSKNASCY FDIEWRDRRITLR ASNGKFVTSKKNGQLAASVETAGDS ELFLMKLINRPII VFRGEHGFIGCRKVTGTLDANRSSY DVFQLEFNDGAYNIKDSTGKYWTVG SDSAVTSSGDTPVDFFFEFCDYNKV AIK VGGRYLKGDHAGVLKASAETVDP
• Sequence Similarities: Belongs to the fascin family.

Gene Information

• Gene Name: FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) [ Homo sapiens ]
• Official Symbol: FSCN1
• Synonyms: FSCN1; fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus); singed (Drosophila) like (sea urchin fascin homolog like) , SNL; fascin; actin bundling protein; FLJ38511; p55; Singed; drosophila; homolog like
• Gene ID: 6624
• mRNA Refseq: NM_003088
• Protein Refseq: NP_003079
• MIM: 602689
• Uniprot ID: Q16658
• Chromosome Location: 7p22
• Function: actin binding; actin filament binding; drug binding; protein binding; protein binding, bridging