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Recombinant Human Cathepsin L1, His-tagged

Cat. No.: CTSL1-405H
Product Overview: Recombinant Human Cathepsin encoding amino acid residues 18-333 of the recombinant human pro Cathepsin L and containing a 6x his-tag at the C-terminus was fused downstream of the CD33 signal peptide. The chimeric protein was expressed inNSO cells.
Description: A cathepsin is a cysteine or aspartic protease, a type of protein that breaks apart other proteins, found in many types of cells including those in all animals. There are approximately a dozen members of this family, which are distinguished by their structure and which proteins they cleave. Most of the members become activated at the low pH found in lysosomes. Thus, the activity of this family lies almost entirely within those organelles. Cathepsins have a vital role in mammalian cellular turnover, e.g. bone resorption. They degrade polypeptides and are distinguished by their substrate specificites.
Source: NSO Cells.
State Of Matter: Frozen.
Formulation: The cytokine is supplied frozen in 50 mM sodium acetate, 0.4 M NaCl, pH 5.0.
Purity: >95% by SDS Page and analyzed by silver stain.
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Biological Activity: The biological activity of Human Cathepsin L was determined by its ability to cleave a fluorescent peptide substrate, N-carbobenzyloxy-Leu-Arg-7-amido-4-methylcoumarin (Z-L-R-AMC). The specific activity, measured with 10 μM Z-L-R-AMC and 1 ng enzyme in 100 μL of 50 mM MES, 5 mM dithiothreitol, pH 6.0, at room temperature, is > 15,000 pmoles/min/μg.
Molecular Weight: The predicted molecular weight of Recombinant Human Cathepsin L is Mr 36 kDa.
Storage And Stability: The frozen protein is stable for 6 months when kept a -20°C to -70°C in a manual defrost freezer. Avoid repeat freeze thaw cycles.
Gene Name: CTSL1 cathepsin L1 [ Homo sapiens ]
Synonyms: CTSL1; cathepsin L1; MEP; CATL; CTSL; FLJ31037; cathepsin L; EC 3.4.22.15; OTTHUMP00000021601; OTTHUMP00000021602; OTTHUMP00000063566; Major excreted protein
Gene ID: 1514
mRNA Refseq: NM_001912
Protein Refseq: NP_001903
MIM: 116880
UniProt ID: P07711
Chromosome Location: 9q21.33
Pathway: Antigen processing and presentation; Lysosome; Diabetes pathways
Function: aminopeptidase activity; cysteine-type endopeptidase activity; kininogen binding; peptidase activity; peptide binding

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