| Description : |
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. |
| Protein length : |
594 amino acids |
| Molecular Weight : |
91.080kDa inclusive of tags |
| Source : |
Wheat germ |
| Tissue specificity : |
Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. |
| Form : |
Liquid |
| Purity : |
Proprietary Purification |
| Storage buffer : |
pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
| Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequences of amino acids : |
MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCT RKLGLKICGFLQRTNSLEEKSRLVSAFKERQSSKNLLSCE NSDRDARFRRTETDFSNLFARDLLPAKNGEEQTVQFLLEV VDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSD HPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGL AGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWS SKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVP KLVLFTSEQSHYSIKKAGAALGFGTDNVILIKCNERGKII PADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDPIQEIA DICEKYNLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVT WNPHKMMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDK QYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQI NKCLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIPQ SLRGVPDSPQRREKLHKVAPKIKALMMESGTTMVGYQPQG DKANFFRMVISNPAATQSDIDFLIEEIERLGQDL |
| Sequence Similarities : |
Belongs to the group II decarboxylase family. |
