Recombinant Human GALE, His-tagged
Cat.No. : | GALE-28967TH |
Product Overview : | Recombinant full length Human GALE with N terminal His tag; 368 amino acids, MWt 40.4kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild (peripheral form) to severe (generalized form). Multiple alternatively spliced transcripts encoding the same protein have been identified. |
Protein length : | 348 amino acids |
Conjugation : | HIS |
Molecular Weight : | 40.400kDa inclusive of tags |
Source : | E. coli |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 10% Glycerol, 0.1M Sodium chloride, 5mM DTT, 20mM Tris HCl, 1mM EDTA, pH 8.0 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MGSSHHHHHHSSGLVPRGSHMAEKV LVTGGAGYIGSHTVLELLEAGYLPV VIDNFHNAFRGGGSLPESLRRVQEL TGRSVEFEEMDILDQGALQRLFKKY SFMAVIHFAGLKAVGESVQKPLDYY RVNLTGTIQLLEIMKAHGVKNLVFS SSATVYGNPQYLPLDEAHPTGGCTN PYGKSKFFIEEMIRDLCQADKTWNA VLLRYFNPTGAHASGCIGEDPQGIP NNLMPYVSQVAIGRREALNVFGNDY DTEDGTGVRDYIHVVDLAKGHIAAL RKLKEQCGCRIYNLGTGTGYSVLQM VQAMEKASGKKIPYKVVARREGDVA ACYANPSLAQEELGWTAALGLDRMC EDLWRWQKQNPSGFGTQA |
Sequence Similarities : | Belongs to the sugar epimerase family. |
Gene Name : | GALE UDP-galactose-4-epimerase [ Homo sapiens ] |
Official Symbol : | GALE |
Synonyms : | GALE; UDP-galactose-4-epimerase; galactose 4 epimerase, UDP; UDP-glucose 4-epimerase; SDR1E1; short chain dehydrogenase/reductase family 1E; member 1; UDP glucose 4 epimerase; |
Gene ID : | 2582 |
mRNA Refseq : | NM_000403 |
Protein Refseq : | NP_000394 |
MIM : | 606953 |
Uniprot ID : | Q14376 |
Chromosome Location : | 1p36-p35 |
Pathway : | Amino sugar and nucleotide sugar metabolism, organism-specific biosystem; Amino sugar and nucleotide sugar metabolism, conserved biosystem; Galactose catabolism, organism-specific biosystem; Galactose metabolism, organism-specific biosystem; Galactose metabolism, conserved biosystem; |
Function : | UDP-glucose 4-epimerase activity; UDP-glucose 4-epimerase activity; UDP-glucose 4-epimerase activity; catalytic activity; coenzyme binding; |
Products Types
◆ Recombinant Protein | ||
Gale-3136M | Recombinant Mouse Gale Protein, Myc/DDK-tagged | +Inquiry |
GALE-1625R | Recombinant Rhesus Macaque GALE Protein, His (Fc)-Avi-tagged | +Inquiry |
GALE-4679H | Recombinant Human GALE Protein, GST-tagged | +Inquiry |
GALE-3741Z | Recombinant Zebrafish GALE | +Inquiry |
GALE-731H | Recombinant Human UDP-galactose-4-epimerase, His-tagged | +Inquiry |
◆ Lysates | ||
GALE-6043HCL | Recombinant Human GALE 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Write a reviewExtensive applications in scientific research and medical fields are found by the protein reagent.
Results repeatability is ensured by the stability of the biomolecular reagent.
Detailed instructions provided by the manufacturer facilitate experimental operation.
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