Recombinant Human GAMT, His-tagged GAMT-28972TH

Recombinant Human GAMT, His-tagged

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Recombinant Human GAMT, His-tagged

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Cat.No. : GAMT-28972TH
Product Overview : Recombinant full length human GAMT fused to His-tag at N-terminus; amino acids 1-236 , 28.4kDa.
Description : The protein encoded by this gene is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes and muscular hypotonia, probably due to creatine deficiency and accumulation of guanidinoacetate in the brain of affected individuals. Two transcript variants encoding different isoforms have been described for this gene.
Conjugation : HIS
Source : E. coli
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Store in the dark. Avoid repeated freeze / thaw cycles.
Gene Name : GAMT guanidinoacetate N-methyltransferase [ Homo sapiens ]
Official Symbol : GAMT
Synonyms : GAMT; guanidinoacetate N-methyltransferase; PIG2; TP53I2;
Gene ID : 2593
mRNA Refseq : NM_000156
Protein Refseq : NP_000147
MIM : 601240
Uniprot ID : Q14353
Chromosome Location : 19p13.3
Pathway : Arginine and proline metabolism, organism-specific biosystem; Arginine and proline metabolism, conserved biosystem; Creatine metabolism, organism-specific biosystem; Creatine pathway, organism-specific biosystem; Creatine pathway, conserved biosystem;
Function : guanidinoacetate N-methyltransferase activity; methyltransferase activity; transferase activity;

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