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Recombinant Human Ectodysplasin A2 Receptor, Fc Chimera

Cat. No.: EDA2R-1701H
Product Overview: Recombinant Human XEDAR containing the signal peptide from human CD33 joined with the extracellular domain of human XEDAR was fused to the Fc region of human IgG1 via a linker peptide, inserted into a suitable mammalian expression vector and expressed inNSO cells.
Description: XEDAR (X-linked Ectodysplasin A2 Receptor) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and induces apoptosis. XEDAR is a receptor for Ectodysplasin-A2 (EDA-A2) which may be a promising agent for the gene therapy of osteosarcoma.
Source: NSO Cells.
State Of Matter: Lyophilized.
Purity: >95% by SDS Page and analyzed by silver stain.
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Molecular Weight: The predicted molecular weight of Recombinant Human XEDAR is Mr 41.8 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 61 kDa.
Formulation: This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Biological Activity: The biological activity of Human XEDAR was determined by its ability to bind rhEDA-A2/His. Immobilized rhXEDAR/Fc at 1 μg/mL (100 μL/well) can bind rhEDA-A2/His with a linear range of 0.045 - 5 ng/mL in a functional ELISA.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Gene Name: EDA2R ectodysplasin A2 receptor [ Homo sapiens ]
Synonyms: ectodysplasin A2 receptor; XEDAR; EDAA2R; EDA-A2R; TNFRSF27; EDA2R; X-linked ectodysplasin receptor; EDA-A2 receptor; X-linked ectodysplasin-A2 receptor; tumor necrosis factor receptor superfamily member XEDAR; OTTHUMP00000023448; ectodysplasin A2 receptor
Gene ID: 60401
mRNA Refseq: NM_021783
Protein Refseq: NP_068555
MIM: 300276
UniProt ID: Q9HAV5
Chromosome Location: Xq12
Pathway: Cytokine-cytokine receptor interaction
Function: protein binding; receptor activity; tumor necrosis factor receptor activity

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