Recombinant Human GMNN, His-tagged

• Cat.No.: GMNN-29013TH
• Product Overview: Recombinant full length protein: Human Geminin fused to His-Tag at N-terminus.

Specification

• Description: This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.
• Conjugation: HIS
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: 0.002% Sodium AzideConstituents: 3mM Sodium chloride, 2.5mM Imidazole, 10mM Tris, pH 8.0
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the geminin family.

Gene Information

• Gene Name: GMNN geminin, DNA replication inhibitor [ Homo sapiens ]
• Official Symbol: GMNN
• Synonyms: GMNN; geminin, DNA replication inhibitor; geminin; Gem
• Gene ID: 51053
• mRNA Refseq: NM_001251989
• Protein Refseq: NP_001238918
• MIM: 602842
• Uniprot ID: O75496
• Chromosome Location: 6p21.32
• Pathway: Assembly of the pre-replicative complex, organism-specific biosystem; Association of licensing factors with the pre-replicative complex, organism-specific biosystem; CDT1 association with the CDC6:ORC:origin complex, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; DNA Replication, organism-specific biosystem
• Function: histone deacetylase binding; protein binding; repressing transcription factor binding