"HDAC10" Related Products

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Recombinant Human HDAC10

Cat.No.: HDAC10-27261TH
Product Overview: Recombinant fragment, corresponding to amino acids 1-481 of Human HDAC10 with N-terminal proprietary tag expressed in a Baculovirus expression system, 79 kDa.
Description: The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Tissue specificity: Ubiquitous. High expression in liver, spleen, pancreas and kidney.
Biological activity: Specific Activity: 1.6 pmol/min/ug.Assay condition : 25 mM Tris/Cl, pH8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 20 uM BPS HDAC substrate, and 20 ng/ul HDAC10. Incubation condition: 30 min at 37oC.
Form: Liquid
Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0
Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities: Belongs to the histone deacetylase family. HD type 2 subfamily.
Gene Name: HDAC10 histone deacetylase 10 [ Homo sapiens ]
Official Symbol: HDAC10
Synonyms: HDAC10; histone deacetylase 10; DKFZP761B039;
Gene ID: 83933
mRNA Refseq: NM_001159286
Protein Refseq: NP_001152758
MIM: 608544
Uniprot ID: Q969S8
Chromosome Location: 22q13.31
Pathway: Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem;
Function: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); enzyme binding; histone deacetylase activity;

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