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Recombinant Human ERBB3

Cat. No.: ERBB3-1613H
Description: V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian), also known as ERBB3 is a member of the epidermal growth factor (EGF) receptor subfamily of receptor tyrosine kinases and is believed to be a receptor for an unknown ligand. ErbB3 has a heregulin (HRG) or neuregulin binding domain but lacks intrinsic protein tyrosine kinase activity. Therefore, it can bind to the ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of ErbB3 and/or over-expression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors.
Source: NSO cells.
Molecular Weight: The predicted molecular weight of Recombinant Human ErbB3 is 96 kDa. However, the actual molecular weight as observed by migration on SDS Page is 130-140 kDa.
State Of Matter: Lyophilized.
Purity: >90% by SDS Page and analyzed by silver stain.
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Biological Activity: The biological activity of Human ErbB3 was determined by its ability to inhibit the biological activity of human Neuregulin-1-b1 on MCF-7 cells. The expected ED50 for this effect in the presence of 10 ng/mL rhNRG-1-b1 is 1.5-6.0 mg/mL.
Storage: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [ Homo sapiens ]
Synonyms: ErbB-3; HER3; MDA-BF-1; MGC88033; c-erbB-3; c-erbB3; erbB3-S; p180-ErbB3; p45-sErbB3; p85-sErbB3; EC 2.7.10.1; ErbB-3; HER3; MDA-BF-1; MGC88033; c-erbB-3; c-erbB3; erbB3-S; p180-ErbB3; p45-sErbB3; p85-sErbB3; EC 2.7.10.1; LCCS2; Receptor tyrosine-protein kinase erbB-3 precursor; Tyrosine kinase-type cell surface receptor HER3; lethal congenital contracture syndrome 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2; Receptor tyrosine-protein kinase erbB-3 precursor; Tyrosine kinase-type cell surface receptor HER3; lethal congenital contracture syndrome 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); ERBB3
Gene ID: 2065
mRNA Refseq: NM_001005915
Protein Refseq: NP_001005915
MIM: 190151
UniProt ID: P21860
Chromosome Location: 12q13
Pathway: Calcium signaling pathway; ErbB signaling pathway
Function: ATP binding ; growth factor binding; nucleotide binding ; protein heterodimerization activity; protein homodimerization activity; protein tyrosine kinase activator activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor activity; transmembrane receptor protein tyrosine kinase activity

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