"FST" Related Products


Recombinant Human Follistatin

Cat. No. : FST-1617H
Product Overview : Recombinant Human follistatinexpressed inSf21 cells using a baculovirus expression system. And A DNA sequence encoding amino acid residues Gly 30 to Asp 329 of the human Follistatin precursor was fused to the signal peptide of human CD33, inserted into a suitable expression vector.
Description : Follistatin (FST) is a glycosylated single-chain protein. It specifically inhibits the secretion of FSH from the pituitary. Follistatin/activin-binding protein binds to heparan sulfate side chains of proteoglycans on the granulosa cell surface to regulate the various actions of activin. Follistatin regulates a variety of biological functions, including cell proliferation, differentiation, and apoptosis. Follistatin plays a critical role in the production of multiple-organ metastasis, predominantly by inhibiting the angiogenesis.
Source : Sf21 Insect Cells.
Molecular Weight : The predicted molecular weight of Recombinant Human FS is 31 kDa. However, the actual molecular weight as observed by migration on SDS Page is 40 kDa.
State Of Matter : Lyophilized.
Purity : >95% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Biological Activity : The biological activity of Human FS was determined by its ability to neutralize Activin-induced bioactivity on K562 cells (erythroid differentiation). The expected ED50 for this effect is typically 0.1 - 0.4 μg/mL in the presence of 7.5 ng/mL of rhActivin A.
Gene Name : FST follistatin [ Homo sapiens ]
Synonyms : EFNA5; ephrin-A5; AF1; EFL5; RAGS; EPLG7; GLC1M; LERK7 ; eph-related receptor tyrosine kinase ligand 7; LERK-7; AL-1; LERK-7; ephrin-A5
Gene ID : 10468
mRNA Refseq : NM_006350
Protein Refseq : NP_006341
MIM : 136470
UniProt ID : P19883
Chromosome Location : 5q11.2
Pathway : TGF-beta signaling pathway
Function : heparan sulfate proteoglycan binding; protein binding; signal transducer activity

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