"IFNGR1" Related Products


Recombinant Human Interferon Gamma Receptor 1

Cat. No. : IFNGR1-57H
Description : IFN-γ receptor ligand-binding chain (IFNγR1) or IFN-γ R α chain, also known CDw119, is member of the class II cytokine receptor family. The IFN-γ receptor is a complex of a high affinity IFN-γ-binding chain (aka, IFN-γ R α chain) and a second accessory protein required for signal transduction known as IFN-γ R β chain. Binding of IFN-γ induces receptor dimerization and internalization. Signal transduction involves Jak1 and Jak2 protein kinases and involves STAT1 activation. The IFN-γ receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes.
Source : NSO Cells.
Molecular Weight : The predicted molecular weight of Recombinant Human IFN-γ R1 is Mr 25 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 40-50 kDa.
State Of Matter : Lyophilized.
Purity : > 95% by SDS Page and analyzed by silver stain.
Endotoxin : < 1.0 EU/µg as determined by the LAL method.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
PDB rendering based on 1fg9. :

Gene Name : IFNGR1 interferon gamma receptor 1 [ Homo sapiens ]
Synonyms : IFNGR1; interferon gamma receptor 1; CD119; IFNGR; FLJ45734; AVP, type 2; CD119 antigen; immune interferon receptor 1; interferon-gamma receptor alpha chain; IFN-gamma-R1; OTTHUMP00000017285; interferon gamma receptor 1
Gene ID : 3459
mRNA Refseq : NM_000416
Protein Refseq : NP_000407
UniProt ID : P15260
Chromosome Location : 6q23-q24
MIM : 107470
Pathway : Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Natural killer cell mediated cytotoxicity
Function : cytokine binding; interferon-gamma receptor activity; receptor activity

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