| Cat.No.: | IMPDH2-28270TH |
| Product Overview: | Recombinant full length Human IMPDH2 with N-terminal His tag. 534 amino acids with a MWt 58kDa including tag. |
| Description: | This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5-monophosphate into xanthine-5-monophosphate, which is then converted into guanosine-5-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. |
| Protein length: | 514 amino acids |
| Conjugation: | HIS |
| Molecular Weight: | 58.000kDa inclusive of tags |
| Source: | E. coli |
| Tissue specificity: | IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor. |
| Form: | Liquid |
| Purity: | >90% by SDS-PAGE |
| Storage buffer: | pH: 8.00Constituents:0.32% Tris HCl, 0.03% DTT, 20% Glycerol, 0.88% Sodium chloride |
| Storage: | Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
| Sequences of amino acids: | MGSSHHHHHHSSGLVPRGSHMADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF |
| Sequence Similarities: | Belongs to the IMPDH/GMPR family.Contains 2 CBS domains. |
| Gene Name: | IMPDH2 IMP (inosine 5-monophosphate) dehydrogenase 2 [ Homo sapiens ] |
| Official Symbol: | IMPDH2 |
| Synonyms: | IMPDH2; IMP (inosine 5-monophosphate) dehydrogenase 2; inosine-5-monophosphate dehydrogenase 2; |
| Gene ID: | 3615 |
| mRNA Refseq: | NM_000884 |
| Protein Refseq: | NP_000875 |
| Uniprot ID: | P12268 |
| Chromosome Location: | 3p21.2 |
| Pathway: | Drug metabolism - other enzymes, organism-specific biosystem; Drug metabolism - other enzymes, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; |
| Function: | DNA binding; IMP dehydrogenase activity; RNA binding; metal ion binding; nucleotide binding; |
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