Recombinant Human Leukemia Inhibitory Factor Receptor Alpha

• Cat.No.: LIFR-1663H

Specification

• Cat. No.: LIFR-1663H
• Description: LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor. LIFR is necessary for the proper development of motor neurons in brainstem nuclei and the spinal cord. LIFR is composed of a heterodimer LIFR alpha and GP130. LIFR alpha is a glycosylated variant of LIFR and is identical with M1 differentiation inducing activity.
• Molecular Weight: The predicted molecular weight of Recombinant Human LIF sRα is Mr 89 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 100-110 kDa.
• Source: Sf 21 Insect Cells.
• State Of Matter: Lyophilized.
• Purity: >97% by SDS Page and analyzed by silver stain.
• Endotoxin: <0.1 ng per 1 µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: LIFR leukemia inhibitory factor receptor alpha [ Homo sapiens ]
• Synonyms: LIFR; leukemia inhibitory factor receptor alpha; SWS; SJS2; STWS; CD118; LIF-R; FLJ98106; FLJ99923; leukemia inhibitory factor receptor; CD118 antigen; LIF receptor
• Gene ID: 3977
• mRNA Refseq: NM_001127671
• Protein Refseq: NP_001121143
• MIM: 151443
• UniProt ID: P42702
• Chromosome Location: 5p13-p12
• Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
• Function: ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding; leukemia inhibitory factor receptor activity; oncostatin-M receptor activity; growth factor binding; receptor activity