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Recombinant Human MET, Fc-His

Cat. No.: MET-1624H
Product Overview: Recombinant Human HGFR was expressed inNSO cells. The extracellular domain of c-Met was fused to the carboxy terminal 6X his-tagged Fc region of human IgG1 via a polypeptide linker.
Description: Hepatocyte growth factor receptor (HGFR), also known as c-Met, plays an important roles in angiogenesis and tumor growth.C-Met is a receptor tyrosine kinase expressed by epithelial cells of the brain, kidney, liver and other tissues. Binding of its ligand, Hepatocyte Growth Factor (HGF), triggers receptor autophosphorylation, and activation of several downstream effectors including the mitogen-activated protein kinases ERK-1 and ERK-2, and PLC-γ. Activation of the c-Met signal transduction pathway leads to mulitple cellular responses including cell motility, scattering, proliferation, survival and angiogenesis.
Source: NSO Cells.
State Of Matter: Lyophilized.
Purity: >95% by SDS Page and analyzed by silver stain.
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Molecular Weight: The predicted molecular weight of Recombinant Human HGF R is Mr 129 kDa.
Formulation: This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Biological Activity: The biological activity of Human HGF R was determined by its ability to bind human HGF. Immobilized rhHGF R/Fc at 1 μg/mL (100 μL/well) can bind rhHGF (0.1 - 5 ng/mL) in an ELISA type assay.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Gene Name: MET met proto-oncogene (hepatocyte growth factor receptor) [ Homo sapiens ]
Synonyms: AUTS9; HGFR; RCCP2; c-Met; HGF receptor; OTTHUMP00000069168; SF receptor; met proto-oncogene; met proto-oncogene tyrosine kinase; oncogene MET; scatter factor receptor; EC 2.7.10.1; HGF/SF receptor; met proto-oncogene (hepatocyte growth factor receptor); met proto-oncogene
Gene ID: 4233
mRNA Refseq: NM_000245.2
Protein Refseq: NP_000236.2
MIM: 164860
UniProt ID: P00533
Chromosome Location: 7q31
Pathway: Adherens junction; Axon guidance; Colorectal cancer; Cytokine-cytokine receptor interaction; Epithelial cell signaling in Helicobacter pylori infection; Focal adhesion; Melanoma; Renal cell carcinoma
Function: Cell proliferation; cell surface receptor linked signal transduction; multicelllular organismal development; protein amino acid phosphorylation

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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