Species : |
Human |
Source : |
HEK293 |
Tag : |
Avi&His |
Protein Length : |
It contains Glu 25 - Thr 932 . |
Description : |
c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling. |
Form : |
Supplied as 0.22um filtered solution in PBS (pH 7.4). |
Molecular Mass : |
The Human HGFR/c-MET Protein has a calculated MW of 104.6 kDa .As a result of glycosylation, the protein migrates as 80-85 kDa under reducing (R) condition (Bis-Tris PAGE) |
Endotoxin : |
Less than 0.05 EU per ug by the LAL method. |
Purity : |
> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC |
Storage : |
The product should be stored at -70°C. Please do not repeated freeze-thaw cycles. |
Reconstitution : |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |