Recombinant Human MXD1, FLAG-tagged

• Cat.No.: MXD1-28856TH
• Product Overview: Recombinant full length Human Mad with Flag tag, amino acids 1-221, MW = 26 kDa,

Specification

• Description: This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Conjugation: FLAG
• Source: E. coli
• Form: Liquid
• Purity: Immunogen affinity purified
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Contains 1 basic helix-loop-helix (bHLH) domain.

Gene Information

• Gene Name: MXD1 MAX dimerization protein 1 [ Homo sapiens ]
• Official Symbol: MXD1
• Synonyms: MXD1; MAX dimerization protein 1; MAD; max dimerization protein 1; bHLHc58; MAD1
• Gene ID: 4084
• mRNA Refseq: NM_001202513
• Protein Refseq: NP_001189442
• MIM: 600021
• Uniprot ID: Q05195
• Chromosome Location: 2p13-p12
• Pathway: Regulation of Telomerase, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem
• Function: DNA binding; sequence-specific DNA binding transcription factor activity; transcription cofactor activity; transcription corepressor activity