||Recombinant full length Human NANS expressed in Saccharomyces cerevisiae; amino acids 1-359 , 40.3kDa.
||This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant.
||Immunogen affinity purified
||Preservative: NoneConstituents: 30% Glycerol, 0.5% Triton-X-100, 50mM HEPES, 30mM Glutathione, 100mM Sodium chloride, 1mM DTT, pH 7.5
||Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
|Sequences of amino acids:
||MPLELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMI RMAKECGADCAKFQKSELEFKFNRKALERPYTSKHSWG KTYGEHKRHLEFSHDQYRELQRYAEEVGIFFTASGMDE MAVEFLHELNVPFFKVGSGDTNNFPYLEKTAKKGRPMV ISSGMQSMDTMKQVYQIVKPLNPNFCFLQCTSAYPLQPED VNLRVISEYQKLFPDIPIGYSGHETGIAISVAAVALGA KVLERHITLDKTWKGSDHSASLEPGELAELVRSVRLVE RALGSPTKQLLPCEMACNEKLGKSVVAKVKIPEGTILT MDMLTVKVGEPKGYPPEDIFNLVGKKVLVTVEEDDTIMEE LVDNHGKKIKS
||Contains 1 AFP-like domain.