Recombinant Human NDRG1, T7 -tagged

• Cat.No.: NDRG1-28796TH
• Product Overview: Recombinant full length protein (Human) fused to T7-Tag at N-terminal end.

Specification

• Description: This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. It is necessary for p53-mediated caspase activation and apoptosis. Mutation in this gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom. Multiple alternatively spliced variants, encoding the same protein, have been identified.
• Conjugation: T7
• Source: E. coli
• Tissue specificity: Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: 0.002% Sodium AzideConstituents: 0.1% Triton X-100, 10mM Tris, 10mM DTT, pH 8.0
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the NDRG family.

Gene Information

• Gene Name: NDRG1 N-myc downstream regulated 1 [ Homo sapiens ]
• Official Symbol: NDRG1
• Synonyms: NDRG1; N-myc downstream regulated 1; CAP43; protein NDRG1; DRG1; NDR1; RTP; TDD5
• Gene ID: 10397
• mRNA Refseq: NM_001135242
• Protein Refseq: NP_001128714
• MIM: 605262
• Uniprot ID: Q92597
• Chromosome Location: 8q24
• Pathway: Direct p53 effectors, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; Validated targets of C-MYC transcriptional repression, organism-specific biosystem
• Function: Rab GTPase binding; cadherin binding; gamma-tubulin binding; microtubule binding; protein binding