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Recombinant Human SERPINI1

Cat. No.: SERPINI1-1670H
Description: Neuroserpin is an axonally secreted serine proteinase inhibitor that is expressed in neurons during embryogenesis and in the adult nervous system and is implicated in the regulation of proteases involved in processes such as synaptic plasticity, neuronal migration and axogenesis. Neuroserpin plays a neuroprotective role, by blocking the deleterious effects of proteolytic enzymes such as tissue plasminogen activator (tPA). A familial form of a neurodegenerative disease, termed familial encephalopathy with neuroserpin inclusion bodies, is caused by the intracellular polymerization and accumulation of mutated neuroserpin, leading to neuronal death and dementia.
Source: E. coli cells.
Sequence: MTGATFPEEA IADLSVNMYN RLRATGEDEN ILFSPLSIAL AMGMMELGAQ GSTQKEIRHS MGYDSLKNGE EFSFLKEFSN MVTAKESQYV MKIANSLFVQ NGFHVNEEFL QMMKKYFNAA VNHVDFSQNV AVANYINKWV ENNTNNLVKD LVSPRDFDAA TYLALINAVY FKGNWKSQFR PENTRTFSFT KDDESEVQIP MMYQQGEFYY GEFSDGSNEA GGIYQVLEIP YEGDEISMML VLSRQEVPLA TLEPLVKAQL VEEWANSVKK QKVEVYLPRF TVEQEIDLKD VLKALGITEI FIKDANLTGL SDNKEIFLSK AIHKSFLEVN EEGSEAAAVS GMIAISRMAV LYPQVIVDHP FFFLIRNRRT GTILFMGRVM HPETMNTSGH DFEEL
Molecular Weight: The molecular weight of Recombinant Human Neuroserpin is 44.6 kDa.
State Of Matter: Lyophilized.
Purity: >96% by HPLC analysis.
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Biological Activity: The biological activity of Human Neuroserpin was determined by its ability to stimulate the proliferation of Rat C6 cells in the range of 0.5 - 0.6 ug/ml.
Storage: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 [ Homo sapiens ]
Synonyms: SERPINI1; serpin peptidase inhibitor, clade I (neuroserpin), member 1; PI12; neuroserpin; DKFZp781N13156; Protease inhibitor 12; DKFZp781N13156; Protease inhibitor 12; Serpin I1
Gene ID: 5274
mRNA Refseq: NM_001122752
Protein Refseq: NP_001116224
MIM: 602445
UniProt ID: Q99574
Chromosome Location: 3q26
Function: peptidase inhibitor activity; serine-type endopeptidase inhibitor activity

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