Native Human NTF3

• Cat.No.: NTF3-29249TH
• Product Overview: Human Neurotrophin 3.

Specification

• Description: The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.
• Source: E. coli
• Tissue specificity: Brain and peripheral tissues.
• Form: Lyophilised
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: The active form of NT-3 is a dimer formed by two identical 119 amino acid subunits that is held together by strong hydrophobic interactions:YAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNS PVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQ TYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT
• Sequence Similarities: Belongs to the NGF-beta family.

Gene Information

• Gene Name: NTF3 neurotrophin 3 [ Homo sapiens ]
• Official Symbol: NTF3
• Synonyms: NTF3; neurotrophin 3; neurotrophin-3; NGF2
• Gene ID: 4908
• mRNA Refseq: NM_001102654
• Protein Refseq: NP_001096124
• MIM: 162660
• Uniprot ID: P20783
• Chromosome Location: 12p13
• Pathway: MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, conserved biosystem; Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem; Neurotrophin signaling pathway, organism-specific biosystem; Neurotrophin signaling pathway, conserved biosystem
• Function: growth factor activity; nerve growth factor binding; neurotrophin receptor binding; receptor binding