"TIE1" Related Products

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Recombinant Human TIE1, Fc-His

Cat. No.: TIE1-1686H
Product Overview: Recombinant Human TIE1 encoding the extracellular domain was fused to the carboxy-terminal 6X his-tagged Fc region of human IgG1, inserted into a suitable mammalian expression vector and expressed inNSO cells.
Description: Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (Tie-1) are novel endothelial cell tyrosine kinase receptors that are essential for vascular development and remodeling in the embryo. They are expressed almost exclusively in endothelial cells. Tie-1 also have a role in the regulatory pathways of early hematopoiesis and angiogenesis. It is upregulated in diseases such as atherosclerosis and rheumatoid arthritis.
Molecular Weight: The predicted molecular weight of Recombinant Human Tie-1 is Mr 107 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 130-140 kDa.
Source: NSO Cells.
State Of Matter: Lyophilized.
Formulation: This recombinant protein was 0.2 µm filtered and lyophilized from a sterile solution containing 20 mM Tris, 0.5 M NaCl and 10% Sucrose.
Purity: >90% by SDS Page and analyzed by silver stain.
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 [ Homo sapiens ]
Synonyms: TIE1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1; soluble TIE1 variant 1; soluble TIE1 variant 2; soluble TIE1 variant 3; soluble TIE1 variant 4; soluble TIE1 variant 5; receptor tyrosine kinase; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; EC 2.7.10.1; JTK14; TIE; Tyrosine-protein kinase receptor Tie-1; OTTHUMP00000008352
Gene ID: 7075
mRNA Refseq: NM_005424
Protein Refseq: NP_005415
MIM: 600222
UniProt ID: P35590
Chromosome Location: 1p34-p33
Function: ATP binding; nucleotide binding; protein binding; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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