Recombinant Human NUMA1 protein, GST-tagged

• Cat.No.: NUMA1-28047TH
• Product Overview: Recombinant Human NUMA1(200 a.a. - 306 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 37.51 kDa
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: NUMA1 nuclear mitotic apparatus protein 1 [ Homo sapiens ]
• Official Symbol: NUMA1
• Synonyms: NUMA1; nuclear mitotic apparatus protein 1; SP-H antigen; structural nuclear protein; centrophilin stabilizes mitotic spindle in mitotic cells; NUMA
• Gene ID: 4926
• mRNA Refseq: NM_006185
• Protein Refseq: NP_006176
• MIM: 164009
• UniProt ID: Q14980
• Chromosome Location: 11q13
• Pathway: Caspase cascade in apoptosis, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Centrosome maturation, organism-specific biosystem; G2/M Transition, organism-specific biosystem; Mitotic G2-G2/M phases, organism-specific biosystem; Recruitment of NuMA to mitotic centrosomes, organism-specific biosystem
• Function: protein binding; structural molecule activity