Recombinant Human OAT

• Cat.No.: OAT-30516TH
• Product Overview: Recombinant OAT protein was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Description: This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome.
• Source: E.coli
• Species: Human
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol
• Molecular Mass: 45.2 kDa (408aa), confirmed by MALDI-TOF.
• Protein length: 33-439aa
• AA Sequence: MTVQGPPTSD DIFEREYKYG AHNYHPLPVA LERGKGIYLW DVEGRKYFDF LSSYSAVNQG HCHPKIVNAL KSQVDKLTLT SRAFYNNVLGEYEEYITKLF NYHKVLPMNT GVEAGETACK LARKWGYTVK GIQKYKAKIV FAAGNFWGRT LSAISSSTDP TSYDGFGPFM PGFDIIPYNDLPALERALQD PNVAAFMVEP IQGEAGVVVP DPGYLMGVRE LCTRHQVLFI ADEIQTGLAR TGRWLAVDYE NVRPDIVLLG KALSGGLYPVSAVLCDDDIM LTIKPGEHGS TYGGNPLGCR VAIAALEVLE EENLAENADK LGIILRNELM KLPSDVVTAV RGKGLLNAIV IKETKDWDAWKVCLRLRDNG LLAKPTHGDI IRFAPPLVIK EDELRESIEI INKTILSF
• Purity: > 90% by SDS - PAGE
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1.0 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: OAT ornithine aminotransferase [ Homo sapiens (human) ]
• Official Symbol: OAT
• Synonyms: ornithine aminotransferase; HOGA; OATASE; DKFZp781A11155; OAT; ornithine aminotransferase, mitochondrial; gyrate atrophy; ornithine-delta-aminotransferase; ornithine-oxo-acid aminotransferase; ornithine--oxo-acid aminotransferase; ornithine aminotransferase (gyrate atrophy); EC 2.6.1.13
• Gene ID: 4942
• mRNA Refseq: NM_000274
• Protein Refseq: NP_000265
• MIM: 258870
• UniProt ID: P04181
• Chromosome Location: 10q26
• Pathway: Arginine and proline metabolism; Metabolic pathways; Metabolism of amino acids and derivatives
• Function: ornithine-oxo-acid transaminase activity; pyridoxal phosphate binding